Tunicamycin (from Streptomyces species), powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Tunicamycin is a mixture of Tunicamycins A, B, C and D. It is a nucleoside antibiotic active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses.
- Presentation: Tan Powder
Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells.
Tunicamycin inhibits many biochemical functions such as synthesis of glycoproteins, procollagen, and peptidoglycans; and IgA and IgE secretion by plasma cells. Blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also affects the fibroblast interferon-cell system.
Soluble in alkaline water, pyridine, hot methanol (4.9-5.1 mg/mL), dioxane ( <1 mg/mL), THF (<1 mg/mL), DMF (>10 mg/mL), DMSO (10 mg/mL), pyridine (>10 mg/mL). Slightly soluble in ethanol (1 mg/mL for 95%), butanol. Practically insoluble in acetone, ethyl acetate, chloroform, benzene and acidic water.
Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells
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Formula:
C₃₉H₆₄N₄O₁₆ MW: 844.95 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00065709 CAS Number: 11089-65-9 |
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