L-α-phosphatidylinositol-4,5-bisphosphate (from porcine) ≥99% (by TLC) Ammonium salt

Supplier: 0000018221

Synonyms: Brain PI(4,5)P₂

840046X10MG 840046X1MG 840046X5MG 840046X25MG

100128-770EA 792.31 USD

100128-770 100123-350 100121-068 100126-690

L-α-phosphatidylinositol-4,5-bisphosphate (from porcine) ≥99% (by TLC) Ammonium salt

L-α-phosphatidylinositol-4,5-bisphosphate

PI(4,5)P₂ plays an important role as a substrate in various signalling proteins though it is a minor component in cell membranes

Liquid

As a subsrate in PI 3-kinase, PI(4,5)P₂ is phosphorylated to PI(3,4,5)P₃ which act as an activator for downstream signaling components such as the protein kinase AKT.

This is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).

MW: 1096.385 g/mol
Storage Temperature: Freezer

CAS Number: 383907-42-4

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