Anti-CD107b Mouse Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: H4B4]

Supplier: Southern Biotechnology

9840-09 9840-09S

100246-532EA 329.54 USD

100246-532 103265-436

Anti-CD107b Mouse Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: H4B4]

Antibodies

CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

Type: Primary
Antigen: CD107b
Clonality: Monoclonal
Clone: H4B4
Conjugation: RPE (R-Phycoerythrin)
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Rhesus, African Green Monkey

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