Chloroquine diphosphate salt

Supplier: MP BIOMEDICALS (FKA ICN BIOMED

Synonyms: N4-(7-Chloro-4-quinolyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate

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IC0219391925EA 105.96 USD
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Chloroquine diphosphate salt
Chloroquine diphosphate salt

Chloroquine Diphosphate salt is member of quinolone family, Chloroquine is a lysosomotropic agent (accumulate inside the acidic parts of the cell), this accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes. Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide).


Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator and to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency.

Formula: C₁₈H₂₆ClN₃
MW: 515.86 g/mol
Melting Pt: 200 °C (dec., lit.)
Storage Temperature: Ambient
MDL Number: MFCD00069852
CAS Number: 50-63-5
EINECS: 200-055-2

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Specification Test Results

Physical Appearance Off-White Powder
pH (1% aq soln) 4.0 - 5.0
pKa 8.4 and 10.8 (for chloroquine base at 20 °C)
Solubility Soluble in water. Practically insoluble in alcohol, benzene, chloroform and ether.
Typical Working Concentration Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 µM

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