BrightSite IRDye Small Animal Imaging Agents are near-infrared fluorescent probes for targeting tumors, bone, lymphatics, vascular structure, and more.
- Validated with cell-based assays, microscopy, small animal imaging, and histology
- Compatible with most small animal imaging systems
- Reactive with implanted tumors derived from a number of cell lines
- Effective in monitoring specific solid tumor models
- Effective for studies dealing with bone metastasis and bone remodeling
They are validated with cell-based assays, microscopy, small animal imaging, and histology to ensure high affinity and specificity
IRDye® 800CW 2-DG is a fluorescent optical imaging agent that has been shown to be reactive with implanted tumors derived from a number of cell lines including A431, SW620, 3T3-L1, and PC3LMN4. IRDye® 800CW EGF Optical Probe is a BrightSite™ near-infrared (NIR) fluorescently-labeled recombinant human epidermal growth factor (EGF). Many types of cancer cells have abnormally high EGFR levels on the cell surface and in vivo assays of EGF binding have proven effective in monitoring specific solid tumor models that exhibit overexpression of EGFR. The ability to visualize bone anatomy and structures for an extended period facilitates use of the IRDye BoneTag in conjunction with a second optical agent specific for a primary target (i.e, tumor tissue). In addition, IRDye 800CW BoneTag may prove effective for studies dealing with bone metastasis and bone remodeling studies.
IRDye® 800CW RGD Optical Probe is a BrightSite™ near-infrared (NIR) fluorescently-labeled RGD imaging agent specifically designed to target the overexpression of integrins on tumors. Integrins are cell surface heterodimeric glycoproteins involved in cell-to-cell and cell-to-matrix interactions. IRDye 800CW PEG Contrast Agent (25-60 kDa) is a non-specific imaging agent intended to exploit EPR in tumor biology.
BrightSite targeting agents are compatible with most small animal imaging systems, including instruments from LI-COR Biosciences (Pearl® Imager and Odyssey® Imager), PerkinElmer (Xenogen, Caliper, CRi, and VisEn), and Bruker (Carestream and Kodak).
