Pertussis Toxin and Virulence Factors, List Biological

Supplier: List Biological Laboratories, Inc.

179A 180 181 186 187

102946-448EA 621.54 USD

102946-448 102946-452 102946-454 102946-458 102946-460 102946-462

Pertussis Toxin and Virulence Factors, List Biological

Microbiology Test Systems Antigen-Antibody Tests Ag-AK, Seren

Pertussis toxin (PT), a virulence factor produced by Bordetella pertussis, is a multi-subunit toxin which binds to most cultured mammalian cells and targets specific G protein, inhibiting the ability of the G protein to function in signaling pathways

Depending on the function of the G protein, the effects of PT can vary. This ability to inhibit pathways utilizing the Gi family of protein-coupled receptors is the basis of the use of PT as a tool in cell biology. PT plays a role in infection by suppressing and modulating various host immune responses to Bordetella pertussis. PT has been used to stimulate experimental autoimmune diseases in rodent models, such as experimental auto immune encephalitis (EAE).

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