Nisin
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Nisin is a polypeptide (34 residues) antibiotic structurally similar to subtilin but containing no tryptophan; a member of the lantibiotic family. Reduces the thermal resistance of bacterial spores in milk-based beverages.The C-terminus of nisin is responsible for the initial interaction of nisin, binding to the target membrane. Active against Gram-positive bacteria at the cytoplasmic membrane.
Antibiotic with bactericidal action. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (requires chelator such as EDTA).
Soluble in dilute acids such as 0.02 N HCl (118 mg/mL). Any undissolved material is the dairy solids and should not be considered a problem. Stable to boiling in acid solutions.
Nisin is a polypeptide (34 residues) antibiotic structurally similar to subtilin but containing no tryptophan; a member of the lantibiotic family. Reduces the thermal resistance of bacterial spores in milk-based beverages.The C-terminus of nisin is responsible for the initial interaction of nisin, binding to the target membrane. Active against Gram-positive bacteria at the cytoplasmic membrane.
|
Formula:
C₁₄₃H₂₃₀N₄₂O₃₇S₇ MW: 3354.06 g/mol |
MDL Number:
MFCD00131724 CAS Number: 1414-45-5 |
|
|
Specification Test Results
| Synonyms | Ambicin N |
| Concentration | Nisin content: 2.5% .Remainder is NaCl and milk solids (denatured). |
| Form | Tan Powder |
| Storage | Store at Room Temperature (15-30 °C). |
| pH | 3.31 (10% aq suspension) (Lit.) |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...