Cycloheximide (microbial) ≥94%, white powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide,
, Naramycin A
, Actidione
Applications
Cycloheximide is used in protein synthesis in apoptosis. It is also used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production.
Product Description
Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. It inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis.
Biochem/physiol Actions
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Formula:
C₁₅H₂₃NO₄ MW: 281.35 g/mol |
MDL Number:
MFCD00082346 CAS Number: 66-81-9 UN: 2811 ADR: 6.1,I |
Specification Test Results
Identity Test | Passes |
Source | Microbial |
Purity (HPLC) | >94% |
FTIR | Conforms to Standard |
Melting Point | 103 - 120°C |
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