Anti-AP3B1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-AP3B1 Rabbit Polyclonal Antibody

Anti-AP3B1 Rabbit Polyclonal Antibody

13384-1-AP-150UL

10082-968EA 462.47 USD

10082-968

Anti-AP3B1 Rabbit Polyclonal Antibody

Antibodies

AP3B1 is the 140-kDa β3A subunit of the adaptor-related protein complex-3 (AP-3), a ubiquitous heterotetrameric complex that is localized to the trans-Golgi network and endosomes and is involved in protein trafficking to lysosomes or specialized endosomal-lysosomal organelles . This complex is composed of two lager subunits (δ and β3A or β3B), a medium subunit (μ3A or μ3B), and a small subunit (σ3A or σ3B). The absence of the β3A subunit (AP3B1) results in the loss of stability of AP3 and leads to degradation of μ3A, to which β3A is directly bound, while the other subunits are variably affected . AP3B1 contains three main domains: the N-terminal head domain, the hinge, and the C-terminal ear domain. It has been reported as a target of IP(7)-mediated pyrophosphorylation . Defects in AP3B1 are the cause of Hermansky-Pudlak syndrome type 2 (HPS2) .

Western Blot: Mouse Thymus Tissue, 1:500-1:5000; IP:COLO 320 Cells, 1:200-1:2000

Type: Primary
Antigen: AP3B1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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