Anti-CD86 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: PO3.1]

Supplier: Tonbo Biosciences

C57Bl/6 splenocytes were unstimulated (left panel) or stimulated for 3 days with LPS (right panel) and stained with 0.125 ug PE Anti-Mouse CD86 (50-0861) (solid line) or 0.125 ug PE Rat IgG2b isotype control (dashed line).

C57Bl/6 splenocytes were unstimulated (left panel) or stimulated for 3 days with LPS (right panel) and stained with 0.125 ug PE Anti-Mouse CD86 (50-0861) (solid line) or 0.125 ug PE Rat IgG2b isotype control (dashed line).

50-0861-U025 50-0861-U100

10051-278EA 51.7 USD

10051-278 10051-280

Anti-CD86 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: PO3.1]

Antibodies

The PO3.1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

The PO3.1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.

Type: Primary
Antigen: CD86
Clonality: Monoclonal
Clone: PO3.1
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity:

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