(Benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate (PyBOP)
Supplier: BACHEM AMERICAS INC
Synonyms:
PyBOP
, 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate
, ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)
Sequence: Benzotriazol-1-yloxy-tripyrrolidino-phosphonium hexafluorophosphate
A trademark of Merck KGaA, Darmstadt, Germany PyBOP is a well-established, effective coupling reagent. It has been developed to replace BOP which generates the carcinogenic HMPT as a by-product during coupling. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.
Formula:
C₁₈H₂₈F₆N₆OP₂ MW: 520.4 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00077411 CAS Number: 128625-52-5 |
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