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You Searched For: Proteins and Peptides

Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.

Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.


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Product Image-77753-190

Dog Recombinant IL-4 (from E. coli)

Supplier: VWR International
Description: Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.

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Product Image-77753-214

Pig Recombinant IL-4 (from E. coli)

Supplier: VWR International
Description: Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.

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Product Image-77753-610

Mouse Recombinant T REG CELL POLARIZING PB (from E. coli)

Catalog Number: (77753-610)
Supplier: VWR International
Description: Cytokines for polarizing T cells into T regulatory cells. T regulatory cells (Tregs) are a subset of T cells that suppress immune function. They are characterized by the expression of CD4, CD25 and Foxp3 and are known to produce immunosuppressive cytokines TGF-β 1 and IL-10. Tregs can be cultured from naive CD4+ T cells by culturing them in the presence of IL-2 and TGF-β 1 with CD3 and CD28 stimulation. In some cases cells are also cultured with neutralizing antibodies to IL-4, IFNγ and IL-12 and/or retinoic acid.

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Product Image-77753-626

Mouse Recombinant NEURAL SCE PB (from E. coli)

Catalog Number: (77753-626)
Supplier: VWR International
Description: Cytokines for mouse neuronal cell culture. Neural Stem Cells (NSC) are self-renewing cells, of the neural lineage, capable of generating neurons (GABA, dopamine and motor neurons), astrocytes and oligodenrocytes. NSCs are marked by expression of Nestin and can be derived from fetal neural stem cells, adult neural stem cells, embryonic stem cells and adult somatic cells.

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Product Image-77753-082

Rat Recombinant IL-3 B (from E. coli)

Supplier: VWR International
Description: Interleukin 3 beta (IL-3 β) is a cytokine that is produced by activated T cells and mast cells. IL-3 β induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells. IL-3 β also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases.

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Product Image-77753-316

Horse Recombinant PDGF-BB (from E. coli)

Supplier: VWR International
Description: Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β, and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β.

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Product Image-77752-734

Mouse Recombinant IL-10 (from E. coli)

Supplier: VWR International
Description: Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.  IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.  Mouse IL-10 is not active on human cells.

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Product Image-77750-326

Human Recombinant MIP-1 B (from E. coli)

Supplier: VWR International
Description: Macrophage inflammatory protein-1 beta (MIP-1 β), also known as CCL4, is  produced by macrophages and functions as a mitogen-inducible cytokine.  MIP-1 β signals through the chemokine receptor CCR5 to chemoattract immune cells.  MIP-1 β induces inflammatory responses, including neutrophil superoxide production.  The MIP-1 β and MIP-1 α heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1). 

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Product Image-77750-496

Human Recombinant IL-17F (from E. coli)

Supplier: VWR International
Description: Interleukin 17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes.  IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin 6 (IL-6), interleukin 8 (IL-8), and granulocyte macrophage colony-stimulating factor (GM-CSF) cytokines.  IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endothelial cell expression of interleukin 2 (IL-2), monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor beta 1 (TGF-b1).  

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Product Image-77750-590

Human Recombinant IL-17AF (from E. coli)

Supplier: VWR International
Description: Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses.

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Product Image-77750-620

Human Recombinant Procalcitonin (from E. coli)

Supplier: VWR International
Description: Procalcitonin is a precursor of the peptide hormone calcitonin. Procalcitonin is mainly produced by the neuroendocrine cells of the lung and thyroid gland, but may be secreted ubiquitously during inflammation or infection. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments: calcitonin, katacalcin, and an N terminal residue. Levels of unprocessed procalcitonin are significantly increased after bacterial infection, inflammation, trauma, or shock.

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Product Image-77751-446

Human Recombinant TGF-B 1 (from CHO cells)

Supplier: VWR International
Description: Transforming growth factor-beta 1 (TGF-β 1) is a member of the TGF-beta superfamily of cytokines. Members of this family exhibit regulatory activity in immunity, proliferation, adhesion, migration, and growth inhibition pathways. TGF-β 1signals through SMAD proteins via the TGF-bRI and TGF-bRII receptors.

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Product Image-77752-020

Mouse Recombinant FGF-BASIC (from E. coli)

Supplier: VWR International
Description: Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. The application of FGF-basic is a critical component for human embryonic stem cell culture systems and is necessary for maintaining human embryonic stem cells in an undifferentiated state.

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Product Image-77751-072

Human Recombinant R-SPONDIN-1 (from CHO cells)

Supplier: VWR International
Description: R-Spondin-1 (RSPO-1) is a secreted growth factor that stabilizes β-catenin and enhances WNT signaling. RSPO-1 is expressed in many tissues and regulates female sex determination, XX gonad development, oocyte differentiation, and hematopoietic stem cell specification. The RSPO-1 stabilization of β-catenin promotes intestinal crypt cell proliferation. This suggests that RSPO-1 functions as a stem cell growth factor and may have therapeutic potential in the treatment of gastrointestinal diseases and chemotherapy-induced intestinal mucositis. Additionally, recombinant RSPO-1 protein is used to initiate and maintain intestinal organoid cultures.

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Product Image-77751-522

Human Recombinant NRG1-B (from E. coli)

Supplier: VWR International
Description: Neuregulin 1-beta (NRG1-β) is one of many alternatively-spliced isoforms of the NRG1 gene and contains a soluble EGF-like domain. The EGF-like domain of NRG1-β signals through the ErbB2, ErbB3, and ErbB4 receptor tyrosine kinases. NRG1-β is an important growth factor involved in neuroinflammation, nerve regeneration, and cardiovascular processes.

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Product Image-77751-334

Human Recombinant FGF-4 (from E. coli)

Supplier: VWR International
Description: Fibroblast growth factor 4 (FGF-4) is a secreted growth factor that is predominantly expressed during bone morphogenesis and embryonic limb development.  FGF-4 is an important growth regulator for stem cells, fibroblasts, and endothelial cells.  FGF-4 contains a single N-linked glycosylation signal.  In-vitro studies suggest that unglycosylated FGF-4 is cleaved into 13 kDa and 15 kDa truncated proteins that have greater biological activity than the wild type 19 kDa FGF-4 protein.  Human FGF-4 shares high homology and is cross-reactive with mouse FGF-4. 

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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