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Description: CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively.
Catalog Number: 102992-624
Supplier: Adipogen


Description: Nampt/visfatin inhibitor. Inhibitor of NAD+ biosynthesis. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively). Apoptosis inducer. Autophagy inducer. Causes premature senescence. Angiogenesis inhibitor.
Catalog Number: 102515-908
Supplier: Adipogen

Small Business Enterprise


Description: R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Reported IC(50) values are 11-14nM .
Catalog Number: 102992-256
Supplier: Adipogen


Description: Antiprotozoal. Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest at the G1 phase. Induces hyperacetylation of histone H4. Apoptosis inducer. Potent anti-angiogenic compound. Decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines. Autophagy inducer in oral squamous cell carcinoma (OSCC) cells. Promotes either self-renewal or differentiation of embryonic stem cells.
Catalog Number: 102987-300
Supplier: Adipogen


Description: Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.
Catalog Number: 102516-304
Supplier: Adipogen

Small Business Enterprise


Description: Amine-reactive blue fluorescent probe.
Catalog Number: 102989-180
Supplier: Adipogen


Description: Cell permeable, non-alkylating, non-thiol, adduct-forming, redox cycling quinone. Intracellular superoxide anion formation/ROS generation inducer. Anticancer agent. Shown to induce cell proliferation, apoptosis, necrosis and necroptosis in vitro, dependent on concentration, time, temperature and cell type. Valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis. Useful as reference compound in characterizing the effects of oxidative stress. Can be used to eliminate any mechanistic ambiguity involving redox cycling quinoids as the source of reactive oxidant species/oxidative stress in biological studies.
Catalog Number: 102988-722
Supplier: Adipogen


Description: Rasfarnesyltransferase inhibitor. Antifungal, antibacterial and herbicidal. Structurally unique natural products. The basic structure of palmarumycin C1 can be modified by a number of hydroxylation, oxygenation, dehydrogenation and chlorination steps. Antioxidant
Catalog Number: 102513-510
Supplier: Adipogen

Small Business Enterprise


Description: p53 inhibitor. Reversibly blocks p53-dependent transcriptional activation. Tool to combat side effects of cancer therapy. Apoptosis inhibitor.
Catalog Number: 102515-874
Supplier: Adipogen

Small Business Enterprise


Description: Potent and selective PPARgamma agonist with no activation of PPARalpha and PPARdelta. Anti-diabetic agent with potent glucose-lowering effects and decreasing insulin resistance in adipose tissues. Stimulates adipogenesis. Apoptosis and cell cycle arrest inducer in several cancer cell lines. Anti-inflammatory. Inhibits vascular smooth muscle cell (VSMC) migration.
Catalog Number: 102516-294
Supplier: Adipogen

Small Business Enterprise


Description: Useful in the fluorescent labeling of proteins. Labeling efficiency with bovine albumin: <gt/> 50%.
Catalog Number: 102991-066
Supplier: Adipogen


Description: Reactive probe containing s fluorescent metal-ligand complex for the determination of nucleotide base sequences.
Catalog Number: 102990-950
Supplier: Adipogen


Description: One of the principal active constituents of St. John's Wort (Hypericum perforatum). Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission (lambdamax: 594nm). Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses (including HIV). This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy. Selective inhibitor of protein kinase C (PKC). Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor (IR). Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.
Catalog Number: 102988-306
Supplier: Adipogen


Description: Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat.
Catalog Number: 102989-038
Supplier: Adipogen


Description: Highly purified product form pectine.
Catalog Number: 102990-042
Supplier: Adipogen


Description: TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
Catalog Number: 102514-310
Supplier: Adipogen


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